Also, they showed that there is a direct association between has‐circ‐0008673 and several clinical indices including larger tumor size, distant metastasis, positive estrogen receptor (ER) status, positive progesterone receptor (PR) status, and might use as a prognostic predicator of overall survival (OS) and disease‐specific survival (DSS).35 The gene discussed is ESR1; the disease is neoplasm.