TMEM127 and cancer: MGPTs also increase diagnostic yield forPV/LPVs in syndromes that may be discordant from a phenotype-directed referral, asobserved in our cohort.[8, 10, 11] SeveralPV/LPVs here were found in genes typically only assessed via MGPT, including geneswith emerging data regarding cancer risks like BAP1, TMEM127, andMITF.[14–16]