BRCA1 and Lynch syndrome: The genes associated with Hereditary Breast andOvarian Cancer syndrome (BRCA1 and BRCA2,“BRCA1/2”) and Lynch syndrome (MLH1MSH2, MSH6, PMS2,EPCAM) were first identified in the early 1990s.[1, 2] Since tinstime, dozens of other genes associated with high- and moderate-penetrance cancerpredispositions have also been identified.[2–5]