APC and Down syndrome: Finally, of 63 patients initially referred for anyother syndrome, 13 had PV/LPVs: 2 in breast cancer-related genes (CHEK2,n = 2 each), 5 in colon cancer-related genes (MUTYHheterozygote, STK11, n = 1 each; APC, n = 3), and6 in other cancer genes (BAP1, MEN1 SDHB, TMEM127,n = 1 each; PMS2 biallelic, n= 2).