As a result, 36 crossover genes of 58 components in XXD were associated with AKI and are shown in Figure 3(a) such as TLR4, ACE, HSPA8, SIRT1, EGFR, HSPA1A, HMOX1, NOS2, NOS1, NOS3, ADRB2, PTGS2, MET, IL-6, CYP2E1, LGALS3, EPHX2, TTR, TNF, SLC22A12, MPO, MTOR, VEGFA, TP53, BCL2, CAPN1, PPARG, KLK1, MB, ALB, CASP1, ICAM-1, NFE2L2, NFKB1, HIF1A, and G6PD. The gene discussed is KLK1; the disease is acute kidney injury.