By constructing component-target and PPI networks, the flavonoids and several hub genes such as luteolin, quercetin, scutellarein, diosmetin, TP53, VEGFA, PTGS2, TLR4, NOS3, EGFR, PPARG, HIF1A, and HMOX1 might be promising for the treatment of AKI. This evidence concerns the gene HMOX1 and acute kidney injury.