The C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene on the metabolic pathway of homocysteine has been associated with DKD presentation and progression in DM2 populations of south Indian [35] and Tunisian origin [36] and in a meta-analysis including several studies [30]. The gene discussed is MTHFR; the disease is myotonic dystrophy type 2.