Experimental results of Zhang et al. [21] using moxibustion to treat cyclophosphamide induced POF showed that moxibustion can effectively promote the expression of E2 and inhibit the expression of FSH and LH, thereby enhancing the ovarian reserve function; when they further explored its mechanism, it was found that this may be related to the inhibition of cell pyrolysis induced by the TXNIP/NLRP3/Caspase-1 signaling pathway by moxibustion. Here, NLRP3 is linked to premature menopause.