For example, Hong et al. published a prediction model for severe acute pancreatitis by using SIRS, albumin, BUN, and pleural effusion [23]; Qiu et al. conducted a model for the prediction of multiple organ failure in moderately severe and severe acute pancreatitis by using HCT, K-time, IL-6, and creatinine [24]; intra-abdominal pressure and body mass index were applied to establish prediction model to evaluate the AP severity [25]. This evidence concerns the gene IL6 and Pleural effusion.