These results indicated that IL6 (OR 1.01, 95% CI 1.004-1.024, P = 0.003), IL8 (OR 1.20, 95% CI 1.08-1.33, P = 0.001), IL10 (OR 1.26, 95% CI 1.08-1.47, P = 0.003), MCP1 (OR 1.01, 95% CI 1.003-1.026, P = 0.004), CD3+ CD4+ T lymphocytes (OR 0.92, 95% CI 0.87-0.98, P = 0.01), CD19+ B lymphocytes (OR 1.11, 95% CI 1.04-1.18, P = 0.001), PCT (OR 1.14, 95% CI 1.04-1.26, P = 0.006), APACHE II score (OR 1.28, 95% CI 1.05-1.55, P = 0.015), and RANSON score (OR 3.57, 95% CI 1.86-6.85, P < 0.001) were potential predictors for OF in AP. Here, IL6 is linked to alkaline phosphatase measurement.