This result appears to reflect waking theta activity in naive (Fig. 4a) and VEH-treated (Fig. 8a) THRSP OE mice; accounts for the behavioral impairments; and indicates that the enhancement of TH levels (Fig. 9a, b) following TH replacement can normalize this, along with improving ADHD behavior, in these transgenic mice. Here, THRSP is linked to attention deficit-hyperactivity disorder.