A similar finding was observed in TCGA lung adenocarcinoma, in which higher BUB1B/BUBR1-expression was significantly correlated with shorter overall survival in patients with intact ATM, whereas no survival difference was observed according to BUB1B/BUBR1-expression level in patients with ATM mutation (Supplementary Figure 4c) [28]. Here, ATM is linked to lung adenocarcinoma.