Hypermethylation of the DCLK1 5’(α) promoter in human colon adenocarcinomas (CRCs), results in the loss of the DCLK1-L isoform and the usage of an alternate β-promoter drives the expression of the DCLK1-S isoform17–19. The gene discussed is DCLK1; the disease is colon adenocarcinoma.