Our assessments also extended to the state of tumour metabolism in metastatic ccRCC samples labelled with the proliferative Ki-67, IDO-1, GLUT-1, and CD73 markers and revealed that the LAG-3 cluster had significantly higher expression of Ki-67 than in those from the two other clusters and higher expression of IDO-1 than those in the TIGIT cluster (Fig. 3e). This evidence concerns the gene NT5E and neoplasm.