Automated single-cell counting was performed, and LAG-3/TIM-3/TIGIT-positive cells were counted, and the mean percentages of receptor-positive cell density were 2.7% for LAG-3, 6.7% for TIM-3, and 3.3% for TIGIT in a total of 41 non-ccRCC individuals. The gene discussed is HAVCR2; the disease is nonpapillary renal cell carcinoma.