Then, our immunohistological analysis for innate immunity revealed that the LAG-3 cluster had significantly higher levels of CD163 than the two other clusters (Fig. 2d), demonstrating that many infiltrating tumour-associated macrophages (TAMs) in tumours belong to the LAG-3 cluster (co-staining of CD68 together with CD163 from a total of 123,460 cells in COHORT 1 samples showed 84.5% concordance in 1163 CD163-positive cells and 983 CD163 and CD68 positive cells). This evidence concerns the gene CD163 and neoplasm.