Herein, we analysed forty-three ccRCC tumour samples from COHORT 1 comprising the LAG-3 (n = 16), TIM-3 (n = 19), and TIGIT (n = 8) clusters for alterations in 160 cancer-associated genes (Fig. 2a). The gene discussed is HAVCR2; the disease is nonpapillary renal cell carcinoma.