Furthermore, two reports demonstrate the functional significance of Vpr in HIV infection of T cells: (1) Vpx and Vpr overcome transcriptional repression of proviruses by the HUSH complex in Jurkat T cells49; (2) Vpr inhibits exonuclease 1-mediated restriction of HIV-1 Infection in T cells50. The gene discussed is EXO1; the disease is HIV infectious disease.