The GATC haplotype rs8176746–rs8176740–rs495828–rs12683493, of which position is coincident with ABO locus, is common in people with non-O blood groups and positively correlated to ACE activity, while blood group O is characterized by intermediate ACE activity.135,137 Variants account for 15% of ACE activity variance, of which rs8176746 and rs495828 may independently reckon 2.8% and 4.9%, respectively.137–139 The ABO variant rs657152 was considered as a significant signal associating with severe COVID-19 in Italian and Spanish cohorts.104. This evidence concerns the gene ACE and COVID-19.