The unexpected neurodegenerative phenotype of LacZ-expressing animals was considered likely to underlie the differences in severity of thermal behavioral phenotypes between Kcna6lacZ/lacZ and Kcna6−/− mice, especially since Gb3 ganglioside accumulation in Fabry disease models was shown to interfere with Trpv1 signaling and heat sensation (Hofmann et al., 2018). This evidence concerns the gene KCNA6 and Fabry disease.