TRPV1 and Fabry disease: The unexpected neurodegenerative phenotype of LacZ-expressing animals was considered likely to underlie the differences in severity of thermal behavioral phenotypes between Kcna6lacZ/lacZ and Kcna6−/− mice, especially since Gb3 ganglioside accumulation in Fabry disease models was shown to interfere with Trpv1 signaling and heat sensation (Hofmann et al., 2018).