From a translational viewpoint, the fact that expressing a mutated APP gene exclusively in the ChPl can alter the cognitive abilities of mice raises the possibility that modifying the expression of APP or targeting APP mutations specifically in the ChPl, a structure accessible from the venous compartment (Spatazza et al, 2013), may represent a novel means to alleviate the burden associated with AD. The gene discussed is APP; the disease is Alzheimer disease.