The 2019 EULAR/ACR criteria for systemic lupus erythematosus (SLE) include positive ANAs at least once as a mandatory criterion, followed by additional criteria separated into seven clinical groups (constitutional, hematological, neuropsychiatric, mucocutaneous, serous, musculoskeletal, and renal) and three immunological ones (antiphospholipid antibodies, complement proteins, and SLE-specific antibodies).1 This evidence concerns the gene VTN and systemic lupus erythematosus.