Two years later the patient developed a symptomatic dilated cardiomyopathy (DCM) with a strongly reduced ejection fraction (23.5%) and functional anti-beta-1-adrenergic receptor antibodies (anti-β1AR-Ab) were found, his AOSD was by that time well controlled and other causes for DCM including cardiac amyloidosis were explored and ruled out. The gene discussed is ADRB1; the disease is dilated cardiomyopathy.