The Alaskan sled dogs were found to have mutations related to Alanine Aminotransferase (ALT) activity, Alaskan Husky encephalopathy, Collie eye anomaly, degenerative myelopathy, dilated cardiomyopathy, factor VII deficiency, and ichthyosis. Here, F7 is linked to hyperinsulinemic hypoglycemia, familial, 4.