Beside a well-documented pro-angiogenic effect [23], PGE2 promotes apoptosis and stimulates growth of tumour stem cells both through the EP2 and EP3 receptors by synergizing with the Wnt/β-catenin pathway, relevant in cancers where the adenomatous polyposis coli (APC) gene is activated [24]. The gene discussed is APC; the disease is neoplasm.