A full understanding of putative anti-inflammatory therapies for glaucoma and their effects on microglia, such as P2X7 receptor inhibition [65, 66], carbon monoxide [67, 68], antibiotics [69, 70], or downstream effectors [10] will help elucidate the role classical and alternative activation pathways play in retinal degeneration. Here, P2RX7 is linked to glaucoma.