Barbie et al. [23] showed that CYT387, as a TBK1/IKBKE/JAK inhibitor, inhibited triple-negative breast cancer proliferation by suppressing the NF-κB and STAT3 activation induced by IKBKE; however, there was almost no inhibitory effect on cancer growth if only JAK activity was suppressed. The gene discussed is NFKB1; the disease is cancer.