Mutations in six genes, namely melanocyte inducing transcription factor (MITF), SRY-box transcription factor 10 (SOX10), snail family transcriptional repressor 2 (SNAI2), endothelin receptor type B (EDNRB), endothelin 3 (EDN3), and paired box 3 (PAX3), can cause WS. Here, EDN3 is linked to Werner syndrome.