In addition to skin cutaneous melanoma (SKCM), the expression of MAN2B1 is generally high in other cancers, including cervical squamous cell carcinoma (CESC), esophageal carcinoma (ESCA), glioblastomas (GBM), kidney renal clear cell carcinoma (KIRC), brain lower-grade glioma (LGG), liver hepatocellular carcinoma (LIHC), and pancreatic adenocarcinoma (PAAD), as shown in Additional file 1: Figure S1A. The gene discussed is MAN2B1; the disease is cancer.