Our data further demonstrate a possible link between endocrinological and neuronal changes in sarcopenia, as we found a significant reduced IGF-I hormonal axis in total in our cohort independent from sex (Table 1) as well as significant correlations of reduced IGF-I concentrations and low MUNIX values and MUSIX values in general (Fig. 2a and b). The gene discussed is IGF1; the disease is sarcopenia.