At present, it is recognized that TAMs are mainly M2 type, as the key factor of cancer-related inflammation, they promote tumor growth and metastasis by releasing various cytokines (such as IL-10, TGF- β, IL-8, etc.)to inhibit effective anti-cancer immunity, stimulate angiogenesis and epithelial-mesenchymal transformation [5–7]. The gene discussed is IL10; the disease is cancer.