It has been proved that macrophages can differentiate into type M1 (classical activation pathway) after stimulation with lipopolysaccharide (LPS) and interferon-gamma (IFN- γ), or into type M2 after stimulation with IL-4 (selective activation pathway), thus playing the role of pro-inflammatory, anti-tumor, anti-inflammatory and pro-tumor. Here, IL4 is linked to neoplasm.