Eight DMCs located in PDCD-1 (cg09031938, cg03903296, cg06291111, cg07281781, cg10057601, cg11532131, cg04789125, cg10994870) and four DMCs located in LAG-3 (cg10191002, cg04153135, cg06157570, cg14292870) were associated with CRC risk in GEO dataset. The gene discussed is PDCD1; the disease is colorectal carcinoma.