Interestingly studies claimed that a strong synergy between the PDCD-1 and LAG-3 inhibitory pathways in tolerance to both self and tumor antigens and argued strongly that dual blockade of these molecules represents a promising combinatorial strategy for cancer, suggesting that they may contribute to T cell apoptosis and reduce autoimmune function jointly, induce tumor-mediated immune suppression (Woo et al. 2012; Lucas et al. 2011; Matsuzaki et al. 2010; Grosso et al. 2009). Here, PDCD1 is linked to cancer.