In addition, in 2017, a Brazilian team showed that the injection of saliva of A. sculptum, a member of the A. cajennense species complex, in mice whose alpha 1–3 galactosyltrasferase was inactivated, produced IgG and IgE anti α-Gal, suggesting that this species of tick endemic to the Amazon could be a vector of this allergy.18 Here, IGHE is linked to allergic disease.