NFE2L2 and hepatocellular carcinoma: Previous studies have shown that MET [6, 25], encoded by the HGFR gene, NRAS [26, 27], a known RAS family oncoprotein, and NFE2L2 [28, 29] promote tumor growth and metastasis in HCC, and their somatic mutation can cause liver carcinogenesis [7, 8, 14, 27, 30].