As our previous report, gC1qR is a critical regulator of PCV2 nuclear egress [36], thus progeny virion production of PCV2RmA were significantly lower than wild type PCV2 at the same initial infection dose, which led to the viral replication levels in 5 MOI of PCV2RmA-infected cells similar to the viral replication levels in 1 MOI of PCV2-infected cells (Fig 8D). The gene discussed is C1QBP; the disease is infection.