PCK2 and infection: Therefore, the lack of accumulation of Th1-primed PEPCK+ T cells in mice with established infections may also be due to a lack of retention in the tissue in the absence of antigen recognition, as previously shown [36], in addition to the altered induction of subsequent T-cell mediated chemokine production, as demonstrated by the reduction in cxcl9 and cxcl10 gene expression at the day 4 timepoint in our A.T. model and shown in Fig 6I.