This article describes three studies designed to evaluate the (i) performance of a point-of-care test against blood specimens with multiple blood disorders; (ii) precision of the test on multiple G6PD finger replicates; and (iii) diagnostic performance of the test on both fingerstick and venous specimens across three point-of-care settings including laboratory settings for venous blood testing (Table 1). The gene discussed is G6PD; the disease is hematologic disorder.