IKZF1 and type 1 diabetes mellitus: These loci were chosen because they belong to the same transcription factor family and are known to be important in B-lymphocyte development with IKZF1 a critical transcription factor.[35] They are also implicated in early-onset Type 1 Diabetes, but their mechanism of action remains unclear.[36,37] Here, we use the gene regulatory networks produced by the SNP Prioritization Pipeline to generate hypotheses regarding the mechanism by which genetic variance may disrupt gene expression in these loci and contribute to Type 1 Diabetes (S8A–S8C and S9A–S9C Figs).