The densest loci identified by our pipeline was the MHC-II locus which accounts for ~50% of the genetic contribution involved in early-onset T1D.[30] The most connected entities in the locus were HLA-DQB1 and HLA-DRB1, which together can form the haplotype DR4, one of two haplotypes which conveys the highest risk for T1D.[34] In addition, Inshaw et al. recently reported HLA-DQB1 and HLA-DRB1 haplotypes DR15-DQ6 (DRB1*15:01-DQB1*06:02) and DR7-DQ3 (DRB1*07:01-DQB1*03:03) were least common in children that were under the age of 7 at the time of diagnosis with T1D.[36]. This evidence concerns the gene HLA-DRB1 and type 1 diabetes mellitus.