Interaction of this CTCF site has been shown by 3C to connect HLA-DQB1 and HLA-DRB1 promoters in an interferon-gamma-dependent manner in Burkett’s lymphoma B-cell line Raji.[44] Although, no individual knockdown or knockout of this cite has been made, siRNA knockdown of CTCF leads to reduced expression of the entire MHC-II locus and interferon-gamma leads to increased CTCF-dependent looping and is associated with increased HLA-DQB1 and HLA-DRB1 expression. The gene discussed is HLA-DQB1; the disease is lymphoma.