Mutations in these genes lead to human genetic skin diseases such as epidermolytic hyperkeratosis (KRT1), ichthyosis vulgaris (FLG), seborrheic dermatitis (ZNF750), psoriasis (LCE3D), and harlequin ichthyosis (ABCA12) [20–24]. Here, ZNF750 is linked to Harlequin ichthyosis.