It is also shown that tumor cells cotreated with TS at 1 μg/ml or TRAIL at 25 ng/ml downregulate the expression of STAT3 target genes (cFLIP, Bcl-xL, ICAM1, VEGF, TRAF1 and the chemokine receptor CXCR4). The gene discussed is TNFSF10; the disease is neoplasm.