Of note, Pdia4−/−Leprdb/db mice showed more effective amelioration of diabetes than the age‐matched Leprdb/db mice as shown by water consumption (right, Appendix Fig S3A), PBG (Appendix Fig S3B), glucose tolerance (Appendix Fig S3D), islet preservation (Appendix Fig S3E), survival rate (top, Fig 2A), and life span (bottom, Fig 2A). The gene discussed is PDIA4; the disease is diabetes mellitus.