Furthermore, Pdia4 significantly increased the expression of two markers, Beclin 1, a key player in the initiation step of autophagy, and LC3‐II, a player in the elongation step of this process, during autophagy in β‐cells (Fig 4B) in agreement with the literature stating that autophagy is linked to diabetes (Yang et al, 2017). The gene discussed is PDIA4; the disease is diabetes mellitus.