Indeed, prior studies have identified multiple mechanisms of DR gene genetic invalidation (as in the case of DCC in colorectal cancer) (Fearon & Vogelstein, 1990), epigenetic downregulation (e.g., for UNC5H family receptors) (Thiébault et al, 2003), or sporadic mutations leading to selective loss‐of‐pro‐apoptotic function (e.g., for TrkC in colorectal cancer) (Ichim et al, 2013). The gene discussed is NTRK3; the disease is colorectal cancer.