DCC and colorectal cancer: Indeed, prior studies have identified multiple mechanisms of DR gene genetic invalidation (as in the case of DCC in colorectal cancer) (Fearon & Vogelstein, 1990), epigenetic downregulation (e.g., for UNC5H family receptors) (Thiébault et al, 2003), or sporadic mutations leading to selective loss‐of‐pro‐apoptotic function (e.g., for TrkC in colorectal cancer) (Ichim et al, 2013).