MBNL1 and myotonic dystrophy type 1: Moreover, DM1 patients have splicing defects and clinical phenotypes that mimic those seen with genetic ablation of MBNL1 and upregulation of MBNL1 suppresses relevant disease phenotypes in DM1 disease models (Mankodi et al, 2000; Kanadia et al, 2003, 2006; Wang et al, 2019).