BTK and systemic lupus erythematosus: In multiple preclinical studies of murine lupus, several distinct BTK inhibitors (including ibrutinib, which has been widely used in the treatment of several B cell malignancies, and fenebrutinib/GDC-0853) reduced splenic germinal center B cells, plasma cells, and various autoantibodies levels, including anti-dsDNA autoantibodies [49, 82].