TNFSF12 and atherosclerosis: In fact, Fernández-Laso et al. who focused on the direct effect of TWEAK on atherosclerosis in diabetic mice (rather than that of the receptors), proposes that the reduction in the presence of inflammatory cells (mostly macrophages) in lesions of TWEAK deficient diabetic mice is due to decreased activation of JAK/STAT, NF-κB, and the expression of proinflammatory cytokines [55].