STAT3 and neoplasm: Reports across a variety of tumor and endothelial cell types have suggested members of the JAK family, SRC and the intrinsic kinase activity of VEGFR-2 as VEGF-induced activators of STAT3 (Bartoli et al., 2003; Chen et al., 2008; Yahata et al., 2003; Yeh et al., 2006; Zhao et al., 2015).