Although endothelial cell-specific STAT3 knockout mice undergo physiologically normal developmental angiogenesis, these mice exhibit defects in tissue repair and decreased recovery from vascular injuries, including myocardial infarction, cerebral ischemia and ischemia-reperfusion injuries (Hoffmann et al., 2015; Wang et al., 2007a,b). This evidence concerns the gene STAT3 and ischemia reperfusion injury.