GLRX3 and cryptococcosis: Cryptococcus neoformans possesses a single monothiol glutaredoxin, Grx4, and mutants lacking Grx4 are defective in growth at host temperature, elaboration of the virulence factors capsule and melanin, maintenance of iron homeostasis, and the ability to cause disease in a mouse model of cryptococcosis (Attarian et al. 2018).