For example, previous stereology studies of microvascular in 7-month-old Tg APP/PS1 mice [9, 64] report reductions in the total Ncap in white matter and a 45% reduction in total Lcap up to 45% and reductions in hippocampal volume up to 30% [8]; in contrast, we did not find these effects in 12-month-old male TgF344-AD. This evidence concerns the gene PSEN1 and Alzheimer disease.