AS reflected by dual‐luciferase reporter gene assay, FOXP3 overexpression inhibited SCP2 luciferase activity; FOXP3 silencing increased luciferase activity of SCP2 in PC cells relative to sh‐NC (Figure 3I), suggesting that FOXP3 could specifically inhibit SCP2 expression in PC cells. This evidence concerns the gene FOXP3 and pachyonychia congenita.