Furthermore, Ueno et al. demonstrated that OATP1B3 mRNA expression is associated with downstream targets of the WNT/ ß-catenin pathway, such as CYP2E1, GS, OAT, AXIN2, and LGR5; and they showed the ratio of RTE/RLE with a cut-off value of 0.9 has 78.9% sensitivity and 81.7% specificity to predict the ß-catenin mutation status of HCC (Ueno et al. 2014). Here, LGR5 is linked to hepatocellular carcinoma.