Finally, changes in COL6A1, COL5A3, COL5A1, COL5A2, COL6A1, COL3A, COL6A1, COL14A1, and LAMA4 contributed the most to the separation between the BCBM and BC samples, which were also within top modules of the 146 DEGs. The gene discussed is COL14A1; the disease is breast cancer.