Finally, changes in COL6A1, COL5A3, COL5A1, COL5A2, COL6A1, COL3A, COL6A1, COL14A1, and LAMA4 contributed the most to the separation between the BCBM and BC samples, which were also within top modules of the 146 DEGs. This evidence concerns the gene COL6A1 and breast cancer.