Finally, changes in COL6A1, COL5A3, COL5A1, COL5A2, COL6A1, COL3A, COL6A1, COL14A1, and LAMA4 contributed the most to the separation between the BCBM and BC samples, which were also within top modules of the 146 DEGs. Here, LAMA4 is linked to breast cancer.