PSIP1 and cancer: Intriguingly, the PWWP domain of PSIP/p75 is also shown to bind H3K36me2 (Zhuet al., 2016) and detected near transcriptional start sites ofHox genes suggesting the possibility of binding of PSIP/p75 to H3K36me2 at TSS and to H3K36me3 at the gene bodies (Pradeepaet al., 2014) SETD2, the only enzyme responsible for H3K36 trimethylation is mutated in cancers and is proposed to function as tumor suppressor (Liet al., 2016;Zhuet al., 2014).