In summary, baicalin can not only reduce the increase in FBG, body weight, and biochemical indicator in serum and urine due to DM, but also slow down the damage of podocytes caused by hyperglycemia by inhibiting the activity of PI3K/Akt/mTOR signaling pathway, thereby delaying the progression of DM-induced DN. This evidence concerns the gene AKT1 and Hyperglycemia.