Immunotherapy, especially inhibitors targeting immune checkpoints, including cytotoxic T-lymphocyte antigen-4 (CTLA4), programmed cell death protein 1 (PD-1), and programmed cell death 1 ligand 1 (PD-L1), has provided promising new approaches to improve the overall survival (OS) of patients with CRC [3–6]. The gene discussed is CD274; the disease is colorectal carcinoma.