Two common genes, POM121C and NPC1, were identified in both VEGAS2 and TWAS of HF and metaCCA analyses, while six common genes, including ALMS1P, GAB2, PAX8, GGNBP2, L3MBTL3, and GATM, identified in both VEGAS2 and TWAS of CKD and metaCCA analyses. The gene discussed is L3MBTL3; the disease is hydrops fetalis.