What the top five GO biological process terms identified from 169 pleiotropic genes and 21 potential pleiotropic therapeutic targets of SGLT2 inhibitors associated with HF and CKD were response to temperature stimulus (GO:0009266), positive regulation of microtubule nucleation (GO:0090063), regulation of microtubule nucleation (GO:0010968), response to heat (GO:0009408), and phagosome acidification (GO:0090383). Here, SLC5A2 is linked to chronic kidney disease.