Among the 169 putative pleiotropic genes, some genes have been detected in the original GWAS meta-analysis, such as KCNQ1 (PmetaCCA = 3.01 × 10−19, PCKD−meta = 9.02 × 10−9) for CKD and ATXN2 (PmetaCCA = 1.87 × 10−9, PHF−meta = 4.90 × 10−8) and FTO (PmetaCCA = 7.54 × 10−147, PHF−meta = 1.21 × 10−8) for HF, indicating that metaCCA have a more statistic power. Here, KCNQ1 is linked to chronic kidney disease.