Consistent to in vitro data, the expressions of p-Akt, p-JAK1 and p-STAT3 in tissues of mice were notably increased in atherosclerosis group; however, these phenomena were completely reversed by lnc-KCNC3-3:1 siRNA1 (Figures 6H–K). The gene discussed is KCNC3; the disease is atherosclerosis.