Finally, BRD4 recognizes K146ac and K187ac on Snail to prevent Snail from interacting with E3 ubiquitin ligase FBX14 and b-Trcp1, thereby inhibiting Snail polyubiquitination and proteasomal degradation, revealing a non-canonical post-transcriptional regulatory function of BRD4 in maintaining cancer cell growth and metastasis (Qin et al., 2019). This evidence concerns the gene SNAI1 and cancer.